Three sides trail PSG by three points ahead of this round's fixtures - Montpellier, Lyon and Toulouse - with the big-spending Parisian side starting to reap the rewards of their off-season cash splurge.
With record signing Argentine Javier Pastore, Kevin Grameiro and Jeremy Menez now in the ranks at PSG, Antoine Kombouare's men head into the clash with third-bottom Ajaccio on an eight-game unbeaten run in the league, having won three on the trot.
France international Menez was in superb form for the national team against Bosnia in midweek and the 24-year-old forward could yet prove to be the best signing of the three.
Second-placed Montpellier will host mid-table Dijon on Sunday without the services of playmaker Geoffrey Dernis, who is out for a month with a calf injury.
They will be jostling for an advantage over Lyon and Toulouse (both level on 17 points) while Lille and Lorient (16) and Rennes (15) are not far off the pace.
Dijon have won only once in their past five matches while high-flying Montpellier's only recent slip up was a 3-0 home loss to PSG.
Lyon should take care of bottom side Nancy on Saturday to keep up the pressure on their rivals having also lost to leaders PSG, 2-0 away last round.
Lyon boss Remi Garde was pleased with the timing of the international break with key players, Chris, Ederson and Yohan Gourcuff afforded a much needed rest.
Not to be discounted, fourth-placed Toulouse face last season's runners-up Marseille, who are languishing in 13th on the table.
Sochaux ended a four game unbeaten streak for Toulouse last round with a 3-0 win but they will be looking to bounce back and pile misery on struggling Marseille on Sunday.
Manager Alain Casanova is hopeful Paulo Machado, Umut Bulut, Ali Adamada and Emmanuel Riviere will be fit to play for Toulouse.
Reigning champions Lille are starting to gain some momentum and lie fifth in the table ahead of a tricky trip to Auxerre.
With interest from Tottenham, Arsenal and Real Madrid for Lille's star Belgian winger Eden Hazard in midweek, Lille will want to divert that attention and focus on the three points as they bid to continue a seven-game unbeaten run.
In other fixtures on Saturday, Brest, still without a win but with seven draws, host Caen, Evian and St Etienne face off in a mid-table battle, while Nice entertain Bordeaux.
On Sunday, strugglers Valenciennes host Sochaux while seventh-placed Rennes face Lorient.