Youth team coach Stefano Vecchi is in charge for the St Mary's visit after Frank de Boer was sacked on Tuesday.
Vecchi is said to be keen to build unity ahead of their Serie A match on Sunday against lowly Crotone and, as a result, called up all the club's star names for the Europa League despite them not being able to play.
Geoffrey Kondogbia, Joao Mario and Gabriel Barbosa were all left out the Europa League list at the start of the season to avoid Financial Fair Play penalties, but travel with the team to England anyway.
Only former Manchester City striker Stevan Jovetic, who couldn’t get a travel visa, and injured Rodrigo Palacio are not making the journey.
The temporary manager has also brought in experienced midfielder Felipe Melo as well as outcasts Jonathan Bibiany and defender Marco Andreolli.
Centre back Antonio Ranocchia, who was sent off against Sparta Prague, also comes in after serving his suspension.
Inter Milan's squad for tomorrow night: Handanovic, Carrizo, Berni; Andreolli, Ranocchia, Ansaldi, Santon, Murillo, Miranda, D’Ambrosio, Nagatomo; Melo, Joao Mario, Kondogbia, Medel, Banega, Gnoukouri, Brozovic; Icardi, Biabiany, Eder, Perisic, Candreva, Barbosa.