The match will reportedly prove crucial to the Dutchman, with club executives likely to make a decision on his future dependent on the result tonight.
The Nerazzurri have suffered three consecutive defeats in Serie A against Roma, Cagliari and Atalanta and are languishing in 14th place in the table.
Midfielder Gary Medel will be absent due to suspension, after TV evidence led to a three match ban for ‘lashing out with the arm’ at Atalanta’s Jasmin Kurtic.
Banega looks set to return to a midfield three, with Marcelo Brozovic and Joao Mario alongside him.
Inter (probable): Handanovic; Ansaldi, Miranda, Murillo, Nagatomo; Brozovic, Joao Mario, Banega; Candreva, Icardi, Eder